25 June 2024

Your dream destination - short example blog post

Nestled in the northeastern corner of Europe, Estonia is a treasure trove of rich history, stunning natural beauty, and vibrant culture. Whether you're a history buff, a nature enthusiast, or a foodie, Estonia offers a plethora of experiences that are sure to captivate. Here's a look at some of the must-see tourist attractions and culinary delights in this enchanting country.

#### **1. Tallinn’s Old Town**

A UNESCO World Heritage site, Tallinn’s Old Town is a well-preserved medieval gem that transports visitors back in time. Wander through cobblestone streets, marvel at the gothic spires of St. Olaf’s Church, and explore the historic Town Hall Square. Don’t miss the Alexander Nevsky Cathedral, a stunning example of Russian Orthodox architecture.

#### **2. Lahemaa National Park**

For nature lovers, Lahemaa National Park is a paradise of unspoiled landscapes. Located just an hour’s drive from Tallinn, this park is home to dense forests, serene lakes, and picturesque coastline. Hike through the Viru Bog, explore the charming fishing villages of Altja and Käsmu, and visit the majestic Sagadi Manor.

#### **3. Saaremaa Island**

Estonia’s largest island, Saaremaa, offers a unique blend of natural beauty and cultural heritage. Visit Kuressaare Castle, a medieval fortress turned museum, and relax in the island’s tranquil countryside. Don’t miss the Kaali Meteorite Craters, a group of ancient craters formed by meteorite impacts.

#### **4. Pärnu**

Known as Estonia’s summer capital, Pärnu is famous for its sandy beaches and vibrant nightlife. Stroll along the Pärnu Beach Promenade, indulge in spa treatments, and enjoy the lively atmosphere of this coastal town. Pärnu is also home to numerous festivals and cultural events throughout the year.

#### **5. Tartu**

Estonia’s second-largest city, Tartu, is the intellectual heart of the country. Home to the prestigious University of Tartu, the city boasts a lively student population and a rich cultural scene. Visit the Tartu Art Museum, explore the historic Toome Hill, and enjoy the vibrant cafés and bars in the city center.

#### **Estonian Cuisine: A Culinary Adventure**

No visit to Estonia is complete without indulging in its culinary delights. Here are some traditional dishes you must try:

- **Kohuke**: A beloved Estonian snack, kohuke is a sweet curd cheese bar coated in chocolate. It’s a perfect treat for a quick energy boost during your explorations.

- **Verivorst**: This traditional blood sausage is a staple during the Christmas season but can be enjoyed year-round. Typically served with lingonberry jam and sauerkraut, it offers a hearty taste of Estonian heritage.

- **Kiluvõileib**: An open-faced sandwich topped with sprats, boiled egg, and a dollop of mayonnaise. It’s a popular dish often served as an appetizer or snack.

- **Mulgi Puder**: A rustic porridge made from mashed potatoes and barley, often mixed with bacon and onions. It’s a comforting and filling dish, perfect for chilly days.

- **Leib**: Estonian black bread, or leib, is a dark, dense rye bread that holds a special place in Estonian cuisine. It’s typically enjoyed with butter, cheese, or cured meats.

Estonia is a destination that promises to enchant visitors with its blend of medieval charm, natural beauty, and rich culinary traditions. Whether you’re wandering through historic towns, hiking through pristine forests, or savoring local delicacies, Estonia offers an unforgettable travel experience. So pack your bags and get ready to discover this hidden gem of the Baltics!

18 March 2021

Intertextuality practice

A) How does U. Eco use the theory of intertextuality to analyse "Casablanca"? 
B) What is the relationship between the theory of intertextuality and the theory of archetypes?

a) Eco begins by analysing the core of the film, the script. He mentions a conversation between two characters in which one wants to tell the other a story, but stresses that she does not know the ending yet. This is exactly how the script was written - being completed during the process of making the film, instead of having been finished before. This marks the intertextual relationship between Casablanca and its own script.

Later, the author mentions another character ordering drinks. Interestingly, Laszlo orders a different drink every time. Plot-wise the action does not make much sense, nor is relevant to the story. Eco assumes that the script writer was simply copying such situations from various other films.

Finally, Casablanca can also be compared to Hamlet. Not because of the plot, but because of how both of them were written. Citing T.S. Eliot, Eco suggests that Casablanca and Hamlet were not the best works of their authors due to numerous different ways their authors meant for the plot to develop and form; eventually, both of them might feel improvised and rushed to the viewer/reader.

b) The theory of intertextuality refers to the relationship between different texts, how they shape and influence one another (for example, a motif from one work can appear, usually in slightly changed form, in another, because of a deliberate effort of the author who is familiar with the former). The theory of archetypes describes a part of the plot - a situation, a dialogue, a character, among others - that has been pre-established and is frequently reused in different texts, in order to provoke a certain reaction in the reader. It does not need to be universal, but rather relevant to a certain genre or society. Therefore, both theories are similar due to the existence of a part of the plot that has not been the original idea of the author, but appeared in the work as a result of them being familiar with particular notions - whether coming from a given text or being an already established idea.

3 February 2021

Postcolonial criticism example [Benjamin Franklin's "Remarks Concerning The Savages Of North America"]

Franklin's article centers mainly around the understanding of kindness from the perspective of Indians.

The first mention of what can be considered a colonialist's interference is the recollection of the meeting with Indians in Pennsylvania; the conversation was supposed to convince the Natives to send several of their young men to a school run by Europeans. That was not the first time, however, that such offer was presented. The men of the tribe, who were previously taught in such schools, were thought by their people after their return as lacking in skills of hunting, speaking their native language, or fighting. Although, despite that, the Natives did not immediately refuse (their conduct of kindness required at least one day of waiting before giving an answer), nor scold the Europeans for their repeated proposal.

Consequently, the issue of those of the Natives that received education from colonialists plays a part in the men's troubled understanding of their identity. They now belonged to both worlds: they could speak English, were familiar with European culture and ethics, yet, at the same time, they were sent back to their hometowns, to live among - now mostly foreign - Indian society, their habits and way of life, where they were found unqualified to participate in their tribe's daily routine.

While, considering the question of identity, it would be tempting to subconsciously refer to the Natives as "strangers", Franklin's article - deliberately or not - seems to portray Europeans as those who were somehow "different". The described meeting of a Minister with the Sasquehanah people is a fitting example of such portrayal. The tribe politely listens and then thanks the cleric for introducing them to the base of the Christian faith, but they are also willing to tell the man the story of a deity of theirs. The minister then gets rather annoyed, calling it a false fable. Both reactions to each others beliefs - the quiet appreciation from the Indians, and the sudden irritation of the priest - portray the later as the one who is not accustomed to his current environment.

Finally, as in any story of the clash of two vastly different societies, the issue of resistance comes to mind. Whereas the word alone is often associated with violence and turmoil (the article itself talks of "savages"), Franklin's text describes an entirely different perspective: the resistance through good manners, politeness, and the will to learn more about each other, which, as suggested by the author, surprised the Europeans more than acts of cruelty would.

2 January 2021

"A Beautiful Young Nymph Going To Bed" - poem analysis from the perspective of new historicism

Swift's characteristic, ironical gimmick can be spotted even before the poem begins – in the title itself. As the reader quickly notices, the Beautiful Young Nymph does not turn out to be a real mythological creature, or even a real, yet sophisticated lady – Corinna is, in fact, a prostitute. However, the misconception of the character draws even further, as the reader – if they are familiar with the 18th-century fashion, especially the feminine attire – might instinctively picture Corinna as a well dressed (albeit still keeping in mind that her beauty might have been purely created by make-up, yet again taking into consideration the time frame), attractive woman. Here, the author's satirical style comes to play yet again; he describes the lady's bedtime routine, detailing the ridiculous amount of various "enchantments" she takes off, therefore revealing her true physical self – a body marked and destroyed by whatever illness the 18th century London, with which Swift was very familiar with, might have had "in-store" for a woman like Corinna. The destruction of Corinna's disguise, mostly by pests, might be interpreted as an allusion to the actual nature of the London society of the 1700s, hidden between a thick veil of appearances and phony refinement.

1 November 2020

Antidepressant Abuse In The United States

The opioid epidemic, despite still being underreported and having its causes and development misunderstood by many, seems to remain in the public consciousness as the face of the issue, the type of medicine abuse that comes to mind first when one is reminded of prescription misuse. However, the focus on prescription opioids, whereas certainly justified by the data and various personal testimonies presented earlier, cannot remain the only focal point when trying to discuss and understand prescription abuse.
Opioids, as sedatives, are one of many types of the substances the misuse of which can produce effects desired by the abuser. The British charity organisation, Mind, provides a general list of the types of mind-altering drugs; one can differentiate between:

stimulants (e.g. methamphetamine; causing excitement, alertness, and insomnia – also responsible for inducing psychosis, albeit of a different type than opiates, as the state begins when the effects of the drug are still present, instead of being the result of a withdrawal),
depressants (e.g. benzodiazepines; provoking the state of relaxation and drowsiness – however, in larger doses, are able to induce aggressive behaviour and anxiety),
opium-based painkillers (e.g. OxyContin; described in detail in the previous chapter),
hallucinogens (e.g. psilocybin; leading to complex visual, auditory, and sensory hallucinations, detachment from one's surroundings, illusion of a spiritual or religious experience, and rapid mood swings).

To provide the reader with the most detailed and comprehensive analysis of the problem, based on adequate sources, as well as create necessary and thorough comparisons between and references to the data introduced earlier, the present chapter will only focus on one type of the listed kinds of substances, depressants. The certain type was chosen in order to keep the rhetoric of the thesis consistent – to still aim the attention at drugs with sedative purposes – and to introduce the reader to yet another prescription medicine widely abused in The United States.
The category of depressants examined in the chapter is benzodiazepines – in particular, the prescription medication Xanax.
RxList defines benzodiazepines as:

“A class of drugs primarily used for treating anxiety, but also effective in treating several other conditions. (...) They work by affecting neurotransmitters in the brain, chemicals that nerves release in order to communicate with other nearby nerves. One of these neurotransmitters is gamma-aminobutyric acid (GABA), a neurotransmitter that suppresses the activity of nerves. (...) excessive activity of nerves may be the cause of anxiety and other psychological disorders, and benzodiazepines reduce the activity of nerves in the brain and spinal cord by enhancing the effects of GABA.”

As with any other class of drugs, benzodiazepines comprise of numerous constituents. Alprazolam is the certain benzodiazepine used in production of Xanax; as stated by MedicineNet, Alprazolam is a “benzodiazepine sedative that causes dose-related depression of the central nervous system. Alprazolam is useful in treating anxiety, panic attacks, insomnia, and muscle spasms.”
Although they are classified as different families of substances, with distinct chemical properties, as well as used in treatment of divergent conditions, benzodiazepines can be called and treated as the “opioids of antidepressants” - because despite the differences in their core nature, the external factors contributing to their abuse and the circumstances surrounding it bear noticeable similarities that can be recognised even by those affected by neither of the issues analysed in the thesis.
In her recent (2018) article for CNBC, Ashleigh Garrison allows the reader to attain general understanding of various aspects of the abuse of Xanax, but also other benzodiazepine-based medicines. The thesis, basing on additional sources, will detail each point and refer to its equivalent from the previous chapter.
However, before the examination of the elements included in the article can begin, one should be able to sense the actual scale of the issue, depicted in the graph below:
 
Even in the graph, a certain similarity can be recorded. The increase in providing prescriptions for benzodiazepines began at the beginning of the 21st century, correspondingly with the time of the rise of opioid painkillers being prescribed. The deaths caused by prescription benzodiazepine abuse (marked by “x”) also started to increase around the aforementioned time – interestingly, lethal cases of the misuse were not recognised before.
Garrison's article begins with data concerning the number of people in The United States officially diagnosed with anxiety disorder – which surpasses forty millions, meaning nearly one out of ten Americans has been affected by the problem. The most recent statistics provided in chapter two reveal that the ratio of opioids being prescribed causes one out of six people being catered with the drug. Although the latter number is one third less than the former, both surpass the half of the considered group (nevertheless, it is important to acknowledge, that not every person suffering with anxiety disorder is treated with benzodiazepines – while the latter number does, in fact, portray the number of those who used opioids).
Next, Garrison presents more detailed numbers of fatal benzodiazepine overdoses. Similarly to opioid-related deaths, the cases have been rising in numbers in the same period of time. While in 1999, there were 1135 reported cases of fatal overdose, the number increased several times during less than twenty years, reaching 8791 deaths in 2015. The prescriptions filled by the patients account for over 13 millions – the author reports that the number equals for 67 percent increase in the sale of the medicines.
Garrison's thought-provoking side remark to the data states:

“Like opioids, there’s plenty of money to be made in the general anxiety-disorder drug market, which includes antidepressants, benzodiazepines and buspirone. In 2014 this sector was valued at more than $3.3 billion in the United States. It’s expected to reach about $3.8 billion by 2020.”

When trying to understand the roots of the high demand for benzodiazepine-based antidepressants, the author quotes the finding of San Diego psychologist, Justin LaPilusa. According to the specialist, most patients develop anxiety disorder in their early twenties, the reason for that being the stress and responsibilities connected to the beginning of adulthood – namely work and social pressure of various origin. LaPilusa reminds the reader that even though the described age group is considered to be adults, they still do not have the necessary mental capability to successfully cope with such tension, therefore falling victim to the plethora of their personal concerns that, in most cases, can only be treated with professional medical help.
The statement is proven correct by the entry published by Substance Abuse and Mental Health Service Administration (SAMHSA) (2012). In their report, Admissions Reporting Benzodiazepine and Narcotic Pain Reliever Abuse at Treatment Entry, SAMHSA divides the number of American patients admitted to several addiction treatment centers by age:

 
As presented in the graph, young adults make up to over a half of all admissions. The number not only explains that this certain age group is at the highest risk of abusing benzodiazepines and developing addiction – it also leads one to the conclusion that such kind of medicines can be highly addictive, if those that begin to use it the most frequently, are also admitted to addiction recovery centers at such rate.
The mentioned root causes leading to being prescribed benzodiazepines for the first time match, in general understanding, the reasons the interviewees in the film Oxyana provided for their abuse of opioids – the stress related to work (or lack of thereof), social factors (being considered “hillbillies” and thus not receiving sufficient attention to the issue), and lack of better ways of help (caused mostly by internal factors in benzodiazepine abuse, and external in opioid crisis).
The next section of Garrison's research deals with the probability of developing dependence. The author bases her findings on the account of yet another professional, Dr Anna Lembke.
According to Lembke, the physical nature of benzodiazepine addiction does not differ considerably from other cases of substance dependence if the chemical properties of the given class of drugs are considered. Since the benzodiazepine-based medicine alters the actions of gamma-aminobutyric acid (GABA), a neurotransmitter responsible for alleviating the intensity of a person's current emotional state, by strengthening the activity of the acid, the patient can cease to experience anxiety and psychological tension much quicker.
However, prolonged or regular use of such drugs, as Lembke remarks, puts the user at risk of their brain becoming “lazy”. As, during the use, the function of GABA does not rely solely on a natural process anymore, but is instead controlled by an external determinant, the neurotransmitters get used to their purpose having become redundant. Consequently, when the usage of the medicine stops, the reduced or completely erased activity of GABA deprives the patient of the ability correctly manage emotions, thus putting them at risk of panic (due to the sudden lack of the natural reponse they expect) and mental anguish.
Such mechanism creates an unfortunate circle of behavioural pattern – the affected person is aware of the treatment causing chemical imbalance and interfering with the innate agency crucial in maintaining emotional stability, yet is reluctant to quit the therapy due to the distress provoked by the absence of the medicine in the system.
The described process is clearly analogous to the general concept of addiction, including opioid dependence. Nonetheless, in case of the discussed kind of anxiety-management medicines, the addicted individual does not usually seek the recreational properties of the medicine, but rather desires to retain the otherwise natural capability of healthy emotion management. Still, it is important to recognise that recreational use of benzodiazepines does exist and is, in fact, the major component of benzodiazepine (Xanax) epidemic; the issue is going to be analysed in greater detail later in the chapter.
The consequences of the failure of the typical actions of GABA are, however, not the only factors that contribute to the development of benzodiazepine dependence. Similarly to opioid withdrawal, the phenomenon is present in this sort of prescription abuse as well. Corinne O’Keefe Osborn (2018) of Very Well Mind lists the most common symptoms of benzodiazepine withdrawal, along with describing its possible results.
The withdrawal syndrome comprises of:

nausea
insomnia
grand mal seizures
general muscle pain and spasms
the feeling of being detached from one's surroundings
panic attacks, anxiety, the risk of becoming clinically depressed

Whereas many of the symptoms are comparable to the signs of opioid painkillers withdrawal, the most detrimental result in the latter case was paranoia – a purely psychological manifestation. The untreated, prolonged benzodiazepine withdrawal, however, is likely to generate discomfort of more physical nature (but not without being accompanied by some psychological aspects as well). As stated by Osborn:

“Benzodiazepine withdrawal can be dangerous when not handled properly. There is a risk that people who quit benzos without a taper [to taper – to narrow gradually] may experience a life-threatening grand mal seizure. If you go into withdrawal without tapering, you also risk experiencing delirium and hallucinations that cause you to lose touch with reality—a terrifying and dangerous experience.”

Although opioid withdrawal and benzodiazepine withdrawal, when extended in time, are constituted mainly by opposite kinds of symptoms, similarities between can yet again be found - they can both lead to a potentially lethal outcome. The story of Kurt's family in the film Oxyana depicts a case of paranoia that motivated a murder-suicide; likewise, Osborn's statement presented above reveals the possibility of life-threatening seizures appearing.
As stated previously in chapter two, exploring one's personal experience is the most fruitful approach in confirming and supporting official research. Quoted below is the account of Tessa Torgesson, provided by Healthine (2018), a former prescription addict, who suffered from benzodiazepine withdrawal syndrome:

“After a few years of using benzos and then heroin, I got to a place where I was able to make the decision to detox. The doctors told me that I would no longer be prescribed benzos and I went into instant withdrawals. (...) I had increased anxiety, insomnia, irritability, and ringing in my ears.”

Garrison names the last part of her CNBC piece What's leading the charge in benzo Rx? Before the author's findings can be further evaluated and supported by external testimonies and input to answer the leading question, it is necessary to familiarise the reader with the general overview of numbers and demographics pertaining to Xanax and other benzodiazepine abuse. By acknowledging the scale of the problem and the groups that are and the highest risk of falling victim to the abuse (as in the analysis of the opioid epidemic) one is more likely to properly understand the roots of the issue and recognise the factors prone to propel it.
The official site of DrugAbuse – An American Addiction Centers Resource submits a summary of the statistics regarding benzodiazepine misuse which states the following:

those addicted to benzodiazepines were first introduced to the drug or drugs by being prescribed a benzodiazepine-based medicine for medical and/or therapeutic reasons (similarly to the cases of opioid abuse),
the most popular names among the benzodiazepines that the patients filled a prescription for are Xanax (Alprazolam), Valium (Diazepam), Ativan (Lorazepam), and Klonopin (Clonazepam),
the substances are most frequently prescribed to people of Caucasian descent (up to 85% of all admissions), males (over 50%), and those over 18 but under 35 years old (over 50%) (the data yet again shows parrarels between benzodiazepine and opioid misuse),
a benzodiazepine medicine is rarely the only or the main substance that the patient abuses; in most cases the drug is an accompaniment to another, usually an opioid, or marijuana (a literal connection between the two discussed kinds of prescription abuse).

The Resource's Mike Loverde further illustrates the provided data by creating a diagram out of the medical records related to benzodiazepine abuse:

 
Once more, the evidence supports the notion that the beginning of the 21st century marked the sudden and steady escalation of benzodiazepine use, inevitably leading not only to the popularisation of said type of treatment, but also to bolstering the number of addicted individuals.
One of the most recognisable characteristics of the opioid epidemic was its connection to certain demographics (Caucasians, eastern United States). In case of benzodiazepine abuse, no link exists that would be as distinctive as in the previously discussed issue; however, the problem does seem to affect a particular area slightly more often than the rest of the country.
A KUTV reporter, Jim Spiewak (2019), reports his findings concerning benzodiazepine addiction in a piece called Addicted Utah. As the title suggests, this specified state met the problem of prescription abuse on a scale big enough to be noticed by mainstream media.
Nevertheless, before studying Spiewak's article, the reader should be introduced to brief facts, relevant to the reviewed question, regarding the state.
Utah is located in the south west of the US; it does not overlap with the areas mentioned in the previous chapter that are affected by the opioid epidemic on the highest scale. The most important data, however, pertains to the racial composition of the state.
Caucasians (non-Hispanic) make up to over 85% of the overall (3,162,000) population – which suggests that the race aspect is likely to play an important role when considering the risk factors of falling victim to benzodiazepine addiction. No ancestry other than European exceeds 3%. Such relation has not been mentioned in Spiewak's report; nonetheless, it should be taken into consideration due to the clear association with the opioid epidemic.
Instead, the article presents a more official information. In just three years (2016-2019) The University of Utah Health provided over 205,000 prescriptions for benzodiazepines, roughly suggesting that 1 out of 15 Utahns use or used some branch of the medicines. Psychiatrist Ky Dorsey, on the work of whom the report is based, states that he believes such high number of prescriptions distributed is unnecessary. He also confirms the threat benzodiazepine withdrawal possesses for the affected:

“When I see patients come in and they've been on them for 10, 15, 20 years and never had the discussion with a doctor previously about coming off of them, that tells me that there is an issue here. (…) The withdrawal syndrome can actually kill you, it can cause your heart rate to go up, your blood pressure to go up to the point where you die.”

But how did the matter of overprescribing come to be in the case of yet another type of medicines? To answer the question, it is necessary to come back to the main focus of the current analysis, the report of Ashleigh Garrison.
The author begins her summary, What’s leading the charge in benzo Rx, with the previously discussed problem, overprescribing benzodiazepines. However, the question of “why” remains – what is the reason behind the spike in recommending the given medicines? What are the roots of the reason itself?
The findings reveal the problem to most likely be caused by primary doctors, with the crucial notice that they do not overprescribe benzodiazepines in order to gain personal or business benefits, but because of yet another instance of “drive-by appointments”. When discussing the increase in endorsing opioid-based treatment, the explanation for the phenomenon was the capabilities of the physicians being insufficient for the number of patients interested in therapy. Referring to the benzodiazepine crisis, Garrison provides a similar resolution – the primary doctors who are usually in charge of supplying prescriptions, do not possess the necessary knowledge, qualifications, and/or experience to recommend a correct way of treating the patient's problems with mental wellbeing.
Nevertheless, such justification raises a substantial objection – if a physician is not licensed to advocate for a certain type of therapy, why are they appointed to do so? Alex Stuckey (2017) of the Salt Lake Tribune seems to have delivered a satisfactory explanation, stating that the age of current doctors and, subsequently, the lack of interest in medical career, as well as inability to pursue it, mostly due to financial reasons, among younger generations of Utahns, is manly to blame:

“Physicians [qualified to prescribe antidepressants/benzodiazepines; psychiatrists] of the baby-boom generation are preparing for retirement more than ever. In 2015, 18 percent of Utah physicians reported plans of retiring within five years, compared to 9 percent in 2010. (...) as more physicians retire from the medical profession, the trend is worsening an ongoing doctor shortage in Utah, experts say. With 207.5 physicians per 100,000 population, the state ranks 43rd in the nation. (...) the shortage is being compounded by problems at the other end of the pipeline: too few residency slots for graduating Utah medical students, rising costs of higher education and lower physician pay compared to other states.”

Unfortunately, the issue does not simply end at the insufficient number of psychiatry graduates. In certain areas, the access to primary doctors, who could, eventually, provide them with a desired medicine, is also restricted. In her report published by Desert News, Wendy Leonard (2018) informs the reader of the alarming trend of a primary doctor being a fast diminishing occupation in the state.
“The number of physicians, clinicians and nurses the state is turning out has always been estimated based on current need, which might have fuelled the shortage of qualified providers Utah is up against. (...) Because the demographics within Utah vary greatly, so do the needs. The entire state could use more primary care physicians. (...) Primary care physicians have a unique opportunity to intervene with patients early on, reducing the incidence of disease and perhaps preventing long-term problems. Yet, the number of primary care providers is dwindling. Utah needs an average of 379 new physicians each year to keep up with population growth, aging, and physician retirement. (...) spread between rural and urban settings that have different health care needs. (...) Perhaps the greatest disadvantage of a scarce primary care presence is growing concern for the mental health of many Utahns, as suicide rates in Utah fall well above the national average.”

In the passage, Leonard touches on various concerns surrounding the matter of overprescribing benzodiazepines, compelling to the analysis presented in the thesis, allowing the reader to understand the phenomenon in greater detail.
First, the author takes into consideration the probable lack of forward-thinking among Utahns (however, the problem is not exclusive to the state). The numerous components, constituting the overall picture and state of a certain area, that are present and decisive at the time being, will presumably change in the years to come. The absence of a specific concern, namely the rise of the number of those suffering from anxiety disorder, in an environment that does not envision the feasible future variations in the composition of the population, creates a shortage of professionals that is going to undoubtedly generate the problem of “drive-by appointments” in the following years. Alas, the eventual acknowledgement of the concern, however vital, is not likely to bring immediate resolution – even if the concern of the lack of younger Utahns pursuing career in medicine became resolved, graduating and acquiring a licence is a time-consuming process that, in case of absence of desired physicians in a given time, leaves those in need of professional help without proper care.
The next point raised by Leonard concerns the noticeable split between the addicted living in rural and urban areas. The division was described in detail when analysing the issue of lack of proper health care and irresponsible medical practices in the places affected by opioid epidemic the most.
Both issues – the opioid and the benzodiazepine abuse – seems to share the core of the issue.  Those in non-urban areas have no access to proper treatment due to insufficient number of physicians, and thus fall victim to “drive-by appointments”, being prescribed opioid-based medicines without appropriate evaluation due to a big number of patients awaiting medical care; the overprescribing then leads to substance dependence. On the other hand, those residing in cities, where the abundance and choice of physicians is usually present, are able to find the doctor willing to recommend opioids, and therefore, to develop (however, the patients looking for treatment in urban areas are usually already addicted, and trying to find a way to obtain the desired prescription – the concern discussed in the previous chapter as well) prescription addiction.
Besides the general division between the aforementioned populations, the author suggests yet another disparity – the differences between the needs of rural and urban communities.
Before the investigation can begin, one should be familiarised with the composition of the population of Utahns. The number of residents of Utah living in rural areas equals 262,825, with the overall number of Utahns slightly exceeding three million (about 1 out of 10 residents does not live in the city).
With the needed data in mind, one can start interpreting further information. The official website of Georgetown University details the reviewed discrepancy.

 
To portray the phenomenon in an easily comprehensible way, it is necessary to start with the study of the broader contrast.
As illustrated on the graph, the division between kinds of limitations favours the residents of cities in each category; the discrepancy is most visible when considering “major activities”. The findings also suggest the general consensus associated with the problem – the rural population experiences more health disadvantages, therefore finding themselves in more frequent need of medical care. The research published by the website supports the thesis:

"The rural population is consistently less well-off than the urban population with respect to health. The rural population is more likely to engage in risky health-related behaviors and to experience higher rates of chronic conditions and activity limitations. Rural residents are also more likely to be uninsured for longer periods of time, and are less likely than urban residents to receive some types of health care, including tests for various chronic conditions. Limited access to health care in rural areas is generally associated with the fact that there are fewer providers. (...) About one-fifth of the U.S. population resides in a rural area. (...) A larger proportion of the rural population than the urban population reports fair to poor physical and mental health. For example, the proportion of rural residents reporting fair to poor physical health is almost one and a half times the proportion of urban residents. (...) Less than 11 percent of physicians in the U.S. practice in rural areas, yet about 20 percent of the population resides in rural areas. Provider recruitment and retention problems in rural areas are related to several factors including lower salaries, geographic isolation from peers and educational opportunities, and fewer amenities such as schools and recreation."

The criteria for “drive-by appointments” and improper medical care seem to have been met in the quoted description. The fragment, however, established a much needed, yet not sufficient picture of the roots of prescription addiction (both benzodiazepine and opioid) in Utah.
As explained at the beginning of the chapter, benzodiazepines are used in treatment of psychological conditions, most of the time related to stress and anxiety. In the piece quoted earlier, Wendy Leonard mentions suicidal tendencies among the population of Utah, an issue connected strictly to disordered mental well-being, the rates of which, according to the author, “fall well above the national average”.
LiveStories proves Leonard's statement true (data per 100,000 population):
 
What can be noticed yet again, is the spike in the numbers at the beginning of the 21st century.
The deduction from the graph and the acknowledgement of high suicide rates in the state, further answers the question of why benzodiazepine abuse happens to be most prominent in Utah – lack of suitable medical care, combined with prevalent suicidal tendencies, creates an environment where the abuse of prescription medicines is expected to flourish.
The preceding accounts and information confirm the premise of the mutual core of benzodiazepine and opioid abuse, as well as the state of Utah being affected by the former the most. The data included in the chapter, presented in a clear and comprehensible form, is positive to inform one (even without them possessing any prior knowledge of the subject) of the issue of benzodiazepine abuse, the reasons behind it, and the consequences to which it inevitably leads. However, as mentioned previously several times, the direct, personal report on any given matter, is likely to paint the most genuine, authentic picture of the issue.
The approach to the to the personal account of those affected by the benzodiazepine epidemic, however, is going to differ partially from the one presented in the previous chapter. While the opioid crisis, as portrayed in Oxyana, was described by the interviewees involved in it who were themselves addicted to the medicine, or directly participated in the epidemic by various other means, the picture included in the present chapter displays the benzodiazepine epidemic as experienced by professionals engaged in investigating its causes, progress, and consequences.
The Benzodiazepine Medical Disaster, a documentary originally published by RTE1, comprises of a series of interviews, concluded by Shane Kenny, an Irish journalist and a former press secretary of Irish government, who struggled with benzodiazepine withdrawal himself, with Heather Ashton (now retired professor of psychopharmacology and psychiatry at Newcastle University) and Malcolm Lader (professor of psychopharmacology at King's University, also retired).
Before the analysis of the documentary begins, it should be recorded that despite the non-American origin of the interviewees, the information covered by the film does not focus solely on the situation in The United Kingdom, but rather presents universal data, centered around the precarious effects of benzodiazepines on human psyche and body that can be contributed to any group or society. Additionally, as during the study of Oxyana, the data provided by the film will be compared to and supported by knowledge attained from various external sources.
Kenny opens the film by mentioning the notorious question of overprescribing; however, the journalist raises a point that has not been acknowledged in the thesis yet. The list of illnesses that benzodiazepines are used to treat has expanded greatly – instead of limiting the use of the medicines to their original purpose, mental problems connected to anxiety, they are now recommended in cases of muscle spasms, sport injuries, ear diseases (Kenny's situation), mild forms of anxiety that could be cared for with other, less hazardous drugs, and are even used as painkillers. Such form of overprescribing does not only fuel the problem, as in case of “classic” overprescribing, but also considerably enlarges the group of individuals exposed to the threat of addiction.
At the beginning of her interview, Ashton and Lader share their opinion on the benzodiazepine epidemic:

“This was, and still is, a real tragedy. People lose their jobs, their income, their relationships, their marriages. What we need is a wake-up call, where we find people who show signs of brain damage, even if it's just functionally, to start. This would act as a catalyst.”

The first part of the stance draws clear comparisons between opioid and benzodiazepine abuse. The interviewees in Oxyana described their dire day-to-day life that resulted from addiction – the need for money being one of the most pronounced issues since the job opportunities had been greatly reduced.
The latter part, however, presents a new – and considerable – issue. They psychological effects of medicine abuse have been analysed in detail, but can the misuse be responsible for physical changes in the user's brain?
Lader himself conducted two studies with the aim to prove his suspicions. By using the imaging method of analysing the structure of the brain (Lader's team handled the research in the early 1980s; no other, credible technique was available at that time), the professor and his colleagues arrived at a concerning conclusion. The patients who used benzodiazepines for several years showed the signs of brain atrophy; interestingly, the subjects were reported to have been of “relatively young age”, meaning the phenomenon was not likely to be attributed to other causes.
However, Lader was not the only one concerned with physical consequences of long-term use of benzodiazepines. As early as 1976, a Tennessee physician, David Knott, spoke openly about his scepticism towards prolonged use of the drugs:

“I am very convinced that Valium, Librium and other drugs of that class cause damage to the brain. I have seen damage to the cerebral cortex that I believe is due to the use of these drugs, and I am beginning to wonder if the damage is permanent.”

Drug companies responsible for manufacturing benzodiazepines do recognise the alarming results of long-time use, and the list of side effects the user can be exposed to is easily accessible. Nevertheless, Kenny acknowledges a piece of information that would be crucial when considering benzodiazepine treatment, yet it is missing – the symptoms connected to misuse or prolonged use of the drugs are usually long-lasting, and unlikely to disappear without medical assistance.
Ashton and Kenny focus on a specific kind of side effects, the withdrawal syndrome, adding more detailed information to what the thesis has already established in connection to the phenomenon.
According to Ashton, approximately 15% of the affected patients report that the acute physical consequences of their benzodiazepine addiction seem to be permanent (“persistent withdrawal syndrome”), whereas the mental disorders, in most cases, cease to continue.
To support Ashton's findings, ABC News Lauren Cox (2008) discloses the account of an American patient, Alison Kellagher, who used Xanax for almost twenty years:

“I went to a psychiatrist and he just immediately prescribed a Xanax, and it was to take every day. (...) I was in a profoundly alerted consciousness, immediately after stopping. It was the feeling of being in terror, but it was just a physiological state of terror. The first three months was 24-7. Then, it started to let up a little bit by three to six months. By a year, I was pretty comfortable. I wasn't 100 percent, but I was functioning and feeling almost normal.”

Although Kellagher does not provide any additional detail in her statement, the first part of the quote, being prescribed the medicine “immediately”, undoubtedly brings to mind the notorious “drive-by appointments”. The second part illustrates Ashton's thesis of the suffering being mainly physiological.
In the subsequent interview, professor Lader introduces the viewer to a significant comparison between benzodiazepines and opioids. According to Lader's findings, benzodiazepine withdrawal is more pronounced and difficult to overcome that heroin withdrawal. He briefly describes his research: by examining a group of patients who struggled with both benzodiazepine and heroin addiction, he collected numerous accounts of the easiness of stopping abusing opioids in comparison to quitting the other drug (with proper medical help). He also mentions the public's reaction to his discovery; apparently, a significant number of people would not believe the research to be conducted properly due to the general belief that heroin is one of the most dangerous drugs present in modern western societies. As a response to the accusations, Lader brings up a regular occurrence – opioid addicts admitted to prison are forced to go cold turkey (to quit the use of the substance immediately, without any preparation, gradually lowering the dose, or medical assistance) on the drug/medicine are able to successfully halt the abuse (however, a professional aid might be present).
Mentioned earlier was the account of report of Tessa Torgeson, who shared her experience with benzodiazepine withdrawal. Torgeson, however, was also a heroin addict, and therefore is able to prove the results of Lader's research by personal experience:

“The benzo withdrawals were worse than cigarettes - and even heroin. (…) I was angry at the doctors that had originally prescribed me ample benzos for the first few years of my recovery. But I don’t blame them for my addictions. In order to truly heal, I needed to stop blaming and start taking responsibility.”

Lader lists yet another aspect of why he believes benzodiazepine withdrawal causes such severe problems – those addicted to opioids do not report their symptoms to be permanent, or even long-term.
But what exactly are those permanent results of benzodiazepine abuse? The list presented below was comprised of the accounts of the patients admitted to Professor Ashton's clinic, who were affected by the issue:

pain in limbs, back, neck, teeth, and jaw
the feeling of being stabbed with needles and pins (paresthesia) in the face and limbs
stiffness of back, limbs, and jaw
seizures, dizziness
hypersensitivity to light, touch, sound, and taste

In rare cases, psychological suffering was also noticed:

recurrence of the original problems, strengthened (anxiety disorder and depression)
disordered concentration, memory loss
insomnia, hallucinations, nightmares
phobias (most commonly agoraphobia)
panic attacks

Evidently, long-term or permanent withdrawal syndrome is not only longer in duration, but also produces more severe results.
To further detail the distressing aspects of benzodiazepine abuse recovery, Kenny reminds the viewer of an interesting fact – in the 1970s, in the USA a different family of medicines was commonly used to treat anxiety disorder and depressive episodes. Known as barbiturates, they were soon replaced with benzodiazepines due to the reports that the users of the former were exposed to a high risk of developing addiction. The mechanism of action present in barbiturates was also considerably different, although still acting on the same neurotransmitters. As stated by MedicineNet:

“Barbiturates are central nervous depressants. They reduce the activity of nerves causing muscle relaxation. They can reduce heart rate, breathing, and blood pressure. Barbiturates affect the neurotransmitter gamma-aminobutyric acid (GABA) that nerves use to communicate with one another.”

Nevertheless, Kenny and Lader agree that the enthusiasm among the general population created by the new, “safer” drug happened to be precipitate and caused mainly by the lack of deeper knowledge of benzodiazepines, and the desire for a medicine that would not cause respiratory problems even in those that were not misusing it. Moreover, NorthPoint Recovery (2017) raises yet another points as to why benzodiazepines quickly rose in popularity:

“Would it surprise you to learn that by 1977 reports indicate Valium was the most commonly prescribed drug? Why? Because Valium makes you feel super duper awesomely fantastic. (...) It may make you feel good for a while, but before long you’ll be hooked on the stuff and go through horrific withdrawal if you try to stop taking it.”

As can be deduced from the passage, recreational use and the euphoria-inducing side effects of benzodiazepines were the main culprits that helped replace one addictive substance with another.
The film concludes with Kenny expressing his dissatisfaction with the fact that, despite nearly half a century of benzodiazepine abuse, the problem still remains widely ignored by the authorities and bodies responsible for the treatment of those affected by it.
Lader responds that he, too, is baffled with the fact, yet cannot find a reasonable answer as to why no sufficient precautions are being taken and the awareness is not being raised appropriately to the scale of the issue. He stresses that he does not want to point fingers at anyone without a concrete proof (or, in his own words, he is “not going in terms of a conspiracy theory, but it's very difficult to avoid wondering what is actually going on here”), yet the lack of explicit action leaves him to try to find his own explanation.
Finally, he admits that, even if for only a minor scale, he feels that his own steps might have played a part in the problem discussed:

“Yes, I do [regret not pushing the issue more actively], I mean I felt that I might have done [it], but there are times that you'd rather like to stop banging your head against the wall.”

Such statement might leave one to speculate whether Lader means his own limitations concerning physical and psychological abilities, or whether there are other obstacles (although he advises the viewer not to make unsolicited assumptions) that prevented him from continuing his work.
As a finishing statement, Kenny emphasises yet another oddity surrounding the benzodiazpine epidemic: that those abusing illegal substances are (in most cases) able to receive appropriate and sufficient help, unlike the victims of drugs sold in pharmacies, who also are usually not informed of the dangers of the usage of the medicine they have been prescribed. He explains his point in a considerate way:

“The legal pharma industry can and has done much good making drugs that save lives and alleviate illness, but there's no excuse for the scandalous neglect of this pandemic, of life-destroying pain and suffering benzodiazepines have caused and continue today. There's no excuse now either for the ignorance or negligence of the medical professionals who often wrongly prescribe them. Governments and health authorities have shamefully failed their societies pandering to “big pharma” because of their economic needs. […] It's long past time that they face up the truth about these drugs and start doing something about it.”

The chapter helped draw attention to those who are supposedly not affected by the opioid epidemic, yet seem to be yet other victims of it. The previous issue, widely ignored itself, when (rightfully) eventually paid attention to and discussed, is likely to be the only one of its kind that is focused on, mostly to the outrageous data and consequences that suddenly enter the minds of those formerly oblivious to it. This leaves the fact of misuse and the severity of side effects of other prescription drugs – however prevalent and no less life-threatening that the abuse of OxyContin – put to the side or perpetually left in the shadows, all the while awareness of the problem appears to be the first and most important step in minimising its asperity, and, ultimately, putting a long-overdue and to the avoidable suffering and difficulties.

27 October 2020

OxyContin Abuse In The United States

The content of the previous chapter centered mostly around opioids and opioid-based medicines as a means to present the commonly abused branch of pharmaceuticals as exemplary of the issue of marketed substance overdoses. The present chapter will share the focus, this time containing a more detailed description, in order to provide the explanation for the previously portrayed problem, and to provide one with the basis for understanding not only the causes of opioid-based medicine addiction, but also similar issues with other types of pharmaceuticals (discussed more broadly in the final chapter).
In order to provide the best approach to comprehending the question correctly, it is necessary to begin with numbers.
The chart displayed below (obtained from the official website of Centers for Disease Control and Prevention (CDC)) discloses the number of various opioid-based medicines prescribed yearly in the United States.

 
According to the data, between the years 2010 to 2012, the numbers of submitted prescriptions seem to have reached their peak, decreasing steadily in the following years. It is substantial to notice that the statistics for the time of opioids being prescribed the most often correspond with the input from the graph included in the previous chapter regarding the highest number of deaths due to prescription opioids.
But the raw numbers alone do not fully illustrate such widespread issue. The featured map, originally published by Market Watch, cites the concentration of patients dependent and/or addicted to prescription opioids per state (years 2012 to 2014).

 
By studying the map, three patterns can be recognised. The density seems to be the highest (marked dark red and dark orange) in some of the most populated states, noticeably California and New York. However, the highest recorded figure for opioid dependence (both pathological and for medical reasons) remains in West Virginia, together with several other states (Kentucky, Tennessee, Louisiana); all of them have a considerably smaller number of inhabitants than the locations mentioned before. Furthermore, except for Nevada, they are all located in the east coast of the United States. Yet another indication that can be derived from the map suggests the issue to be of much less prevalence in the mid-country, notably in Wyoming, South Dakota, Nebraska, Kansas, and Iowa (as well as in Hawaii and Alabama).
Now that the data presented above has been detailed, the reason for the phenomenon must be identified as well. Is the given states being affected (or safe from) the opioid epidemic a purely coincidental occurrence, or is there a factor, or even a number of factors, that contribute to the problem and the lack of thereof in the specific areas?
For the purpose of presenting the question in a clear and easily understandable manner, one should start the analysis with the human factor, as those affected are the core focus of the issue.
 
The map included above depicts the United States population as divided by ethnicity. Noticeably, the states described as the most affected by prescription opiate addiction are mostly inhabited by white people of European descent (in regards of the “American” ethnicity: those are the Americans of overwhelmingly white European heritage that do not refer to themselves as e.g. Polish American or being a person of French, Czech, and Portuguese descent, but instead choose to identify as simply American, thus not entertaining the fact of the United States being a “nation of immigrants”). California and New York appear to be the exceptions, however this is due to the large populations of these areas: the states have subsequently 72.7 and 58.3 percent of inhabitants of Caucasian origin.
Besides the racial aspect, there are few more similarities that need to be touched on; the most significant ones can be found in the article Why does opioid dependence vary so dramatically by U.S. State? by Allesandra Malito and Quentin Fottrell (2018) of Market Watch.
The authors mention the poor financial situation of the inhabitants of certain states as one of the most important factors leading to opioid abuse. At first, such statement might seem contradictory – since developing prescription opiate addiction requires frequent use of the medicine, normally with dosages increasing over time, struggling financially should prevent the pathological behaviour, not prompt it. Malito and Fottrell puncture the discrepancy; it is the alternative ways of treatment that are expensive, or at least more expensive than opioid-based painkillers.

“Americans on a low income may not be able to afford alternative care or surgery, which effectively means they would have more need for opioid prescriptions to deal with chronic pain. Another problem: Some people may not be able to take time off work and/or may not be able to pay to travel to clinics for regular care.”

To illustrate the issue in a greater detail, and bring a compelling perspective to the question, essential to study and compare the average income in the areas influenced by opioid painkiller abuse, with those where the problem is not as severe.
The census provided by United States Census Bureau (USCB), covering the years 2013-2017, (USCB divides its directory of places ranked by household income for 56 areas – including five unincorporated territories of the United States, e.g. Guam Island, and Puerto Rico) positions the most affected state, West Virginia, as 51st (1st being the highest household income) – making it the most financially underprivileged of all states. Other areas concerned with a large scale of the issue, Louisiana, Kentucky, and Tennessee, were ranked subsequently 48th, 45th, and 42nd, further proving the point of the lack of money being one of the causes of pathological painkiller used.
To create a comparison, the states mentioned above as those with the least amount of opioid prescription addicts, rank at 4th (Hawaii), 20th (Wyoming), 22nd (Nebraska), 26th (Iowa), 30th (South Dakota), and 31st (Kansas).
Another point brought up by the authors of the article, is the correlation between the amount of time spent filling in a prescription, and the time that further examination or introducing the patients to alternative methods of treatment require. Clearly, prescribing a medicine (which, as acknowledged in the previous chapter, is usually the one the patient has known and used for the longest time, and trusts its properties) is a lot less time-consuming practice than recommending treatment based on the individual's specific needs and abilities (most of the time also financial). Such process might, paradoxically, steam from the doctor's desire to treat as many sufferers as possible – a prescription will help alleviate the pain at least temporarily for a large number of people, while focusing on a single case for a longer period of time is likely to prevent some of the patients from receiving even a short-lived relief. Malito and Fottrell call such system “drive-by appointments”.
Sadly, the problem with physicians being at least partially responsible for the opioid epidemic is not limited to just their lack of time – the lack of proper care and the absence of doctors themselves are also the deciding factors.
The authors quote Dr Akash Bajaj's analysis of the issue, which also connects it to the previous point:

“In less populated states like Kentucky and West Virginia, there is a tendency to practice more traditional pain management techniques, which may rely heavily on medications as this approach is quick, cheap and, in the short run, can be effective (...) However, as we have seen this problem can quickly spiral out of control due to the need to take more medication to achieve the same effect.” He insists that instead of practicing the "drive-by appointments", doctors should rather “(...) focus more on definitive therapy, identifying the problem and treating as specifically as possible, without medication management.”

Dr Bajaj also discloses another malpractice that can be observed among physicians, presumably the most vile one of those already mentioned in the chapter. He suggests that certain doctors might take advantage of their patients being reliant on opioid-based painkillers, whether because of their financial struggle, not being suggested any alternative treatment, or already developed physical and/or mental dependence, to assure the sufferers would need their service again. The doctor describes the process with an evident critique of it:

“There are some doctors who will indulge a patient’s desire for painkillers, which often take the form of opioids, in order to keep their practices afloat. This is not good for the patient or the practice. (...) Of course, this is not good for the patient or the practice and, thankfully, there has been a crackdown on such practices.”

As, after presenting the data, certain painkiller abuse appears to take on the most severe form in particular areas, most of the time linked together by the aspects of household income and ethnicity, with the situation worsened by medical malpractices, one cannot forget the places that do not necessarily meet the criteria for being at risk of facing the abuse (at least as long as the financial aspect is taken into consideration), yet a part of their inhabitants still suffers from prescription addiction.
Dr Bajaj, who works in California, thus presumably being familiar with the inconsistency, characterises its most probable cause:

“(...) it’s easier for patients to find opioids when there are more physicians to choose from. In more populated states like California (...) patients are more willing to doctor shop until they find someone willing to give them what they think they need. This is not only a violation of ethics, but can put the patient’s life in danger.”

However, keeping in mind the specifications of prescription abuse demonstrated by Malito and Fottrell, such analysis would imply that those already suffering from opioid dependence, would chose searching highly populated areas as a means of acquiring the medicine; them permanently residing in California or New York would not be the cause of their problem, but rather fuel it shall it already exist.
The authors, however, begin to clarify the inconsistency at the end of their article – more specifically, when they refer to Dr Bajaj's statement about “doctor shopping”.
In more populated areas the number of physicians is, undoubtedly, considerably bigger than in less inhabited states; consequently, the number of patients rises as well, but with more doctors to chose from they are generally not forced to wait for treatment, such as those in the areas where there are no alternatives. This situation eliminates the issue of “drive-by appointments”, allowing the doctors to focus on an individual and suggest various methods of therapy (even the costly ones – the average household income in California places the state at the 5th place, whereas New York ranks 15th).
Sadly, with one problem being solved, another seems to have occurred; doctors being able to pay the patient the appropriate amount of time, supposedly lowering the amount of opioids being prescribed, did not cause the number of white people from highly populated areas overdosing on prescription painkillers to decrease.
Thus, the cause of the problem appears to have no logical connection to any of the reasons presented by Malito and Fottrell – the arguments of low income, medical malpractice, and lack of medical centers are no longer.
The 2019 investigation by Joseph Friedman, David Kim, Todd Schneberk, Philippe Bourgois, Michael Shin, Aaron Celious, and David Schriger, Assessment of Racial/Ethnic and Income Disparities in the Prescription of Opioids and Other Controlled Medications in California, introduces the reader to an intriguing hypothesis that aims to answer the raised question. According to the authors, what propels the epidemic in the particular community, are not reasons of the affected living in a specific place, with certain living conditions; rather, it is the racial bias towards ethnicities other than Caucasian expressed by the doctors in charge.
One might yet again notice a discrepancy in such account. Had the physicians' decisions been fueled by racial antipathy towards a given group, in this instance, all except Caucasians, they would prescribe addictive substances to patients of ethnicities other than white – which, considering the racial component of the opioid epidemic, seems to be the exact opposite. While this perspective is legitimate, the authors suggest a contrasting approach to understanding the dilemma:

 “(...) Hispanic patients were 2 times less likely to receive analgesics following long bone fractures than white patients, after accounting for other factors. Similar discrepancies in pain medication prescribing were found for black patients relative to white patients. Recent studies have found that healthcare professionals often underestimate the pain of black patients when compared with white patients and that such racial/ethnic biases in the detection of pain are seen among healthcare professionals who report no explicit racial/ethnic biases. These gaps, coupled with decreased access to the healthcare system for many racial/ethnic minority groups, have led several authors to suggest that there is a national crisis of insufficiently medicated pain among minority communities in the United States. In light of a similar gradient in opioid overdose deaths, these disparities in opioid prescription may have played an accidental protective role in minimizing the opioid epidemic among minority communities.”

The detailing of the approach does, in fact, inform one of the existence of the issue, as well as helps recognise the reason for excuse for other ethnic groups being less likely to be affected by the epidemic. Nonetheless, the authors do not provide any interpretation as to why such bias would be held and executed by physicians (“the roots of this racial/ethnic phenomenon have not been adequately explained”).
The answer seems to be at least suggested in the 2017 interview Dr Andrew Kolodny gave for the National Public Radio:

“Something that we do know is that doctors prescribe narcotics more cautiously to their non-white patients. It would seem that if the patient is black, the doctor is more concerned about the patient becoming addicted, or maybe they're more concerned about the patient selling their pills, or maybe they are less concerned about pain in that population. But the black patient is less likely to be prescribed narcotics, and therefore less likely to wind up becoming addicted to the medication. So what I believe is happening is that racial stereotyping is having a protective effect on non-white populations.”

Kolodny's commentary grants a sensible resolution to the aforementioned hypothesis. The reason for such perception or prejudice in physicians remains the matter of discussion that would no longer center around prescription opioid abuse, however, assuming that the objective is valid, the painkiller abuse in highly populated areas that maintain a high household income appears to be logically justified.
Nevertheless, one should keep in mind, that even though Caucasians might be perceived as more responsible and less likely to be involved in drug abuse and trafficking by physicians, they should not be blamed for the practice; unless there is a legitimate, proven case of a white patient persuading the doctor to be prescribed a medicine for the reasons acknowledged above, no group can not be held accountable for the favouritism of other group (particularly if such bias is inclined to lead to a damaging outcome, indicating that Caucasians suffer the effects of the epidemic regardles of their financial status and various external factors).
After detailing the exception of California and New York being included in the list of places severely affected by opioid prescription abuse, it is pertinent to concentrate back on the prevalent form of the problem. It remains a fact that financially underprivileged eastern states continue to be at the top of the record of suffering areas. Malito and Fottrell's article contributes greatly to the justification of the phenomenon; it does, however, paint only the general picture of the issue. It does not introduce one to any individual case of a suffering person that would expose their feelings (towards their own struggle, as well as the opiate epidemic in a more broad sense), and maybe even provide examples of instances leading to the problem that the article failed to include. Focusing on a personal account of those directly involved is crucial to understanding not only the issue presented in the thesis, but should also be considered as the leading method in familiarising oneself with any given point of interest.
The 2013 documentary Oxyana allows one to be meet with the opportunity to do so.
Although the makers of the movie did not state it in any public statement, the viewer might assume that the year the film was released was not chosen coincidentally. Obviously, the general time of the release is consistent with the time of the opioid epidemic being treated as a widespread issue in the United States, but, more precisely, 2013 marks a spike in the abuse after its decrease in the prior few years (as depicted in the diagram presented in the previous chapter). Albeit it only a hypothesis, the production of the film might have been scheduled as such for a reason similar to the picture being analysed in this chapter – to help those interested in the issue (but also the people affected by it, as their involvement does not necessarily equal a full comprehension of the reason for the situation they found themselves in) understand its causes and ramifications more easily, while not omitting any significant facts that are seemingly too detailed or unaffiliated.
Even though the analysis itself is going to comprise of the first-hand experience of those affected, as stated earlier, their accounts might be occasionally supported by scientific data and other external piece of information. Such exercise is not by any means supposed to suggest that the individual struggle of the people presented in the film can only be considered valid if it has been officially recognised by external sources, but to yet again demonstrate that the mechanics of addiction are similar in both illegal substance and prescription abuse.
The official statement of Sean Dunne, the director of the film, lets the viewers familiarise themselves with the incentive that prompted the production, as well as allows for the anticipation of even more personal experience, as it corresponds with the victims' own accounts presented in the picture.
Taken from the official website for the film:

“It wasn’t long after I first set foot in Oceana, WV that I knew something wasn’t right. In fact, something was desperately wrong. This was one of the most beautiful places I had ever seen, filled with hands down the most honest and welcoming people I had ever met. Yet there it was, a constant and growing hum of anxiety. So we started to ask questions, and we started to get answers, all pointing towards a familiar narrative. Greed that led to overprescribing pharmaceuticals that led to addiction that led to poverty, lawlessness and hopelessness. Each story we’ve heard is more harrowing and haunting than the previous. Here is a place that represents our failures as a country, a microcosm of everything that’s gone wrong with the American Dream. Oxyana. These stories needed to be seen; they needed to be heard. Residents who were once talented, charismatic, hard working, God fearing, normal people have been reduced to nothing by the uncontrollable lure of this pill. There are high school girls with $800/day habits and families, who literally can’t provide food for their children, yet have full prescription bottles. There are former miners who have turned to dealing to make ends meet and pregnant women selling their bodies for another fix. It is a seemingly endless line of people who have lost the will to live.”

Obviously, the analysis will start at the very beginning – of the statement and of the film.
The action takes place in a relatively small town, Oceana. The viewer is probably not going to be surprised to discover that Oceana is situated in West Virginia, the state where the issue of opioid painkiller addiction has been proven to be the most prevalent and severe.
The title of the film, however, seems to be a word play on the name of the town. The place's “new” name comes from the drug OxyContin – which is another unsurprising fact when one takes into account the data presented earlier in the chapter (however, the director made opioid painkillers the main focus of his production, but the story touches on other types of abused medicines as well).
The film begins with various shots depicting Oceana – presented in an ominous, quiet, almost unsettling manner that one might interpret as a cinematic metaphor for the lethargic state opioids bring the user into. Overall, the film comprises of series of interviews given by the residents of the town that have been affected by prescription abuse (for easier differentiation, some of the interviewees will be given a fictional name, since their actual identities have not been revealed in the production); each one of them shares their exclusive experience, concentrating on a specific issue they struggle with the most.
The first interviewees, Patrick and Courtney, share their feelings towards Oceana as their hometown. Their account appears to be nothing short of positive – they praise the landscape, the long-lasting friendships, even the strong desire to keep coming back to the town, which, yet again, suggests the viewer the analogy of the early relationship between the user and the drug, when the former is usually still oblivious to the negative consequences of the still-developing habit.
According to Mayo Clinic's report on the development of opioid addiction:

“The length of time you use prescribed opioids also plays a role. Researchers have found that taking opioid medications for more than a few days increases your risk of long-term use, which increases your risk of addiction. The odds you'll still be on opioids a year after starting a short course increase after only five days on opioids.
A number of additional factors — genetic, psychological and environmental — play a role in addiction (...)”

Taking a habit that can sometimes last for years (as documented later in the film) into account, a few days might not seem to be a long period of time. However, the recreational effects of the medicine can easily be noticed during even a short-time treatment (especially in a first-time user that has not developed any kind of substance tolerance in the past), and the decision of continuing the use for non-medical purposes can clearly be made.
It is also worth mentioning that Patrick and Courtney's initial praise of Oceana as a place located in a beautiful natural environment which was once great and safe for raising children suggests a person's usual original perception of legally marketed medicines as not being harmful to the customer.
The next interviewee, Dominic, the local dentist, supports his neighbours' view of the town as something they are very attached to, at the same time realising that such mindset creates a sort of a contradiction, the existence of something an outsider would not suspect when experiencing the life in the town only superficially. He voices his concern:

“There's this darkness that has come over it, that has affected all those things in a way that it's even affected the natural beauty of this place, because as a person that lives here I almost can't look at it the same, because the people don't trust each other as they used to (…) there's more crime, the “us against them” mentality, and it's incredible, and amazing, and awful, all at the same time.”

The director then shows Courtney again (for future reference, she is the mother of another interviewee, Jason), who, referring to Dominic's statement, describes the beginnings of the epidemic in Oceana.
According to the woman, the town fallen victim to the phenomenon about fifteen years ago. She admits that at first she believed overprescribing the medicines was to blame, yet diminished the belief later, as even before the start of the epidemic, the use of cannabis and alcohol was prevalent in Oceana, but was noticeably less damaging than opioid abuse – therefore, she was not convinced that overuse of the medicines would be more risky than smoking or drinking. Some time later, however, she realised that the substances were considerably different from each other, and that the consequences of abusing prescription opioids were evidently more severe.
Business Insider (2016) provides a chart – a comparison of the level of addictiveness among chosen groups of substances – that validates Courtney's reflection:
 
All three components – pleasure, psychological dependence, and physical dependence – are marked as having the strongest properties when attributed to heroin, i.e. an opioid based substance. In comparison, the two other substances of interest, alcohol and tobacco, possess a lower risk of addiction, and, interestingly, a visibly smaller level of pleasure derived from the use. Such combination of factors seems to have contributed not only to heroin/opioids being placed at the top of the chart, but also to have explained what happened in Oceana.
Following Courtney's remark, the viewer is introduced to a twenty-three years old man, Aidan, who brings up his perspective concerning the lethality of prescription abuse in Oceana.
Aidan's age seems to have been mentioned purposefully. He remembers his expectations concerning high school – picturing it like the stereotypical American schools one can see in a film for teenagers and young adults – that, sadly, were not met at all. Instead, what he encountered was “kids would just slap the pills down your hand”. Now, few years after graduating, he tells the interviewer about the shock he experienced when he found out that numerous of his high school friends were already dead (which means they died before the age of twenty three) due to prescription opioid overdose.
His surprised reaction, while justified as a personal experience, involves a phenomenon that has already been unveiled and described by professionals.
As reported by Henry J Kaiser Family Foundation, the number of fatal opioid overdoses in West Virginia tends to be the highest among young adults (followed by people after the age of thirty-five up to forty-four).
The testimony and data presented above – as in several other cases described earlier – seems to be contradictory to the consensus or the generally held perception regarding the portrayed issue. Why would high school graduates, or even those who are still students, that most probably have already made plans for their future, be it academic or private, indulge in such destructive behaviour?
While the film does not directly answer the question – it does not describe the exact causes of the decision – it does in fact detail the palpable conditions that accompany the situation.
As stated by an Oceana native, Nikolai:

“When the prescription drug pill OxyContin hit the market the whole game changed. People started ripping each other off, they started breaking into people's homes, to fuel the addiction. That, to me, has been the biggest downfall of the area.”

Furthermore, the following account of two next interviewees, Vivienne and Isabel, supports Nikolai's statement by omnipresence (also among the young) of the problem, and touches on the root of it:

“It's an epidemic here. Anybody you could talk to here will tell you that they've at least dabbled in something [some prescription medicine]. They might not have gotten addicted to it, but they at least fooled around it. (…) Because there's nothing to do, this is such a small place, you look around, there's mountains everywhere. In big cities they've got movie theatres, and malls – we don't have anything like that to go and just do something.”

Although resorting to substance abuse as a result of boredom might seem reckless and worthy of contempt, especially in the age of easily accessible digital entertainment and means of communication whose use is almost effortless, it is not a rare occurrence.
Boredom, as understood by its traditional definition – lack of stimuli providing entertainment – does indeed play a role in developing addiction, however, to fully comprehend the issue, one should look for a broader interpretation of idleness.
Overwhelming routine – be it, as in the case of Oceana, plain, usually unenjoyable environment, or hours spent daily in a mundane workplace – can also create the feeling or emptiness and stagnation. Additionally, when worsened by the experience of abuse (of any kind and severity), the sense of boredom can evolve into the impression of being trapped, which, naturally, leads to the affected being tempted to employ whatever form of escape they are able to find, physical or, as in the situation in question, psychological.
In her piece for MedMark, Holly Holloway (2018) provides more details related to the connection of addiction and the provided, wider definition of boredom:

“Doing drugs or drinking can provide somewhat of a mental vacation from people’s current situation. When someone feels trapped and doesn’t know what to do with themselves, getting high or drinking can provide the same kind of mental stimulation as doing a fun  activity. Many of these people are also dealing with profound loneliness, anxiety, or are suffering from other situations that prevent them from being involved with hobbies or activities. People with anxiety and depression may feel that leaving their homes to engage in social activities is too stressful, and instead, prefer to stay home and numb themselves.”

Even though job-related routine was mentioned earlier as one of the reasons for developing addiction, lack of employment contributes to the issue as well (which might seem likely, if one associates unemployment with lack of sufficient physical activity or failing to pursue other areas of interest – such assumption might be, to a degree, correct, if individual cases are being taken into account, however, that is not what contributed to the development of the prescription addiction epidemic in Oceana.)
The city of Oceana, as one can derive from the film, used to be the place that profited mainly from coal mining. When, no longer than three decades ago, the industry in the area decreased in profitability, the problem of unemployment became evident, as most of the inhabitants were not trained in alternative employment fields.
Such kind of material hopelessness, as Erika – a single mother – and Stacy – pregnant at the time of the interview, as well as one of the earlier interviewees, Vivienne  – describe, lead to rapid increase of women that decided to become prostitutes (all three of them admit to having been involved in the practice).
Nonetheless, the additional income they received from prostitution, was not solely supposed to support the basic needs of the household. That was, as Vivienne describes, the time when the abuse of various other prescription medicines increased in Oceana. She describes the situation as a simple action-consequence equation: the inability to find employment fuelled depressive tendencies in inhabitants, who, consequently, turned to professional help. Yet, as mentioned earlier in the thesis, the people fell victim to drive-by appointments, where they did, in fact, receive the necessary prescription, but were not provided with sufficient guidance as to how to benefit from the medicines safely; therefore, the misuse of the drugs put the patients at the risk of developing dependence, which, in many instances, became the case.
This does not mean, obviously, that misuse of antidepressants and other non-opioid medicines did not exist in Oceana at the time when the coal mining industry was flourishing – the interviewees, however, try to paint the picture of what they themselves experienced. They did allocate their newly earned money to their and their families' needs, but the “needs” had become more than bills and food – they had to also include the obtained prescription. At the beginning, to improve their mental well-being, and later – to support the addiction (although, in the vast majority of cases, in order to produce desired effects, non-opioids were abused as simply an addition to opioids – not separately; this resulted in even bigger financial problems, as those struggling with dependence had to be able to purchase more medications).
In the interview, Vivienne relives her family's material striving:

“My dad is also addicted, me and him used together. [We] won the lottery, twelve thousand dollars (…) in one week it was gone, we had nothing left, we did 1080s [a reference to the dose of the abused medicine] every day. (…) I was scared, because... my husband, the reason he went to jail was because he was trying to support my pill habit, and I didn't have to do nothing, I sat at home all day, and he went out and robbed coal mines (…) so when he went to prison I had to step up and take that responsibility. (…) I sold one OxyContin for eighty dollars once and there were five people fighting over it. (…) I needed six to eight hundred dollars to actually get high. If I was lucky then I would actually get high daily.”

It is worth nothing that Vivienne mentions selling a single pill for a high price – such a black market for medicines also came to existence in Oceana. It was not often comprised of people like Vivienne, who decided to give up one need to satisfy another – instead, even those that were not affected by the epidemic directly, still participated and contributed to its escalation. By taking advantage of “drive-by appointments”, they would easily obtain the required prescription, to later illegally sell the medicine by highly inflated price.
Such activity, however, is not exclusive to places like Oceana, where the opioid epidemic has spread on such enormous scale – the data presented below, provided by United States Sentencing Commission (USSC), outlines the details of the felony, and further clarifies the reasons as to why it would eventually take place in Oceana.
USSC reveals that:

the majority of those convicted with illegal prescription opioid trade (as of 2018) were Caucasians (contributing to over fifty percent of the convicts); interestingly, the figure for black people was also considerably high: over thirty two percent (whereas Hispanics make up to slightly over ten percent of the convicted),
almost all of the convicts were American citizens (nearly ninety seven percent); USSC did not, however, disclose the nationality of the remaining three percent,
half of the convicted had no prior criminal records (a situation comparable to the position of the women in Oceana that had decided to get involved in prostitution, and then unlawfully sell some of their medicines); less than five percent of the convicts were disclosed as career offenders,
West Virginia was revealed to be the state with the third highest number of the people charged with the offence (nineteen convicts) – overtaken by Kentucky (twenty six) and Pennsylvania (thirty).

Additionally, almost seventy percent of the prison sentences related to the offence were shorter than five years; only thirteen percent of the prison sentences surpassed ten years of imprisonment.
One can yet again notice the pattern already discussed in the thesis several times. In this instance, however, Caucasians seem to contribute directly to the development of the epidemic (high number of convicts); similarly, the sole involvement of black people appears to be greater as the ones distributing the drug than those abusing it.
As presented before, the race of the addicted plays a significant role in distinguishing the opioid epidemic from other issues of said type. Whereas it is mainly considered as the factor contributing to the proneness to establish dependence, Oxyana presents the racial aspect as not only a cause of the problem, but also an obstacle in overcoming it.
In their interview, Joy and Victoria, a couple, describe how the negative stereotype associated with Caucasians and eastern states like West Virginia pertain to the issue of prescription opioid addiction being overlooked and downplayed by the general population of the US:

“If you had a quarter of addiction that we've been through, you would understand completely, you wouldn't even ask that question, you'd be like, damn, how are you still alive? (…) You know what? Nobody's going to care, you know, this is West Virginia, they think we're all much inbred pieces of shit. People are actually trying [to overcome the addiction], but you cannot get anywhere... It just sucks, man.”

Such approach to the issue – the diminishment and contempt preventing the victims from getting much needed help – together with other aspects contributing to the problem, yet again outside of the sufferers' control, (namely lack of proper medical care in their area of living) is likely to help one become more aware of the severity of it in terms of external factors being partially responsible for the victims' hardship.
It is vital to recognise that the word “partially”, pertaining to the fault of extrinsic factors contributing to the scale of the problem within certain individuals, was not used coincidentally. The thesis neither supports, nor suggests victim blaming, both as a general point of view, as well as in the question examined; nevertheless, in order to properly explain and understand the given subject, all aspects and sides of it need to be presented (especially when the direct account of those involved is available).
This specific point in question is being discussed in the film by yet another couple, James and Rena. After introducing himself, James provides the brief description of his current and past position:

“I have a problem, I have cancer, and I've been on drugs since I was twelve years old, but I've been on oxycodone since two thousand and seven. I have an addiction, plus I'm fighting cancer. So these are two fifteens [shows the drugs on the table], I'm ready to do one for me and one for my wife. This is how I do it [injects himself, then Rena, in the back of the palm].”

That short scene raises several points that ought to be detailed further, together with the main issue of personal responsibility.
James admits to have been involved in the consumption of drugs as early as in middle school. While such statement might appear shocking to the viewer, drug abuse in children is, in fact, an authentic phenomenon. An article from The Journal of the British Paediatric Association, Drug Abuse In Children And Adolescents, published in 1992 (which is probably the approximate time of James' childhood), provides the figures and specific elements for the abuse in the US:

“National American surveys usually report higher rates [as compared to Great Britain]. Most dramatic in the USA is the increase in cocaine use: in 1985, over 1,1 million 12-17 year old adolescents had tried cocaine. (...) Overall about 5% of adolescent drug abusers in the USA meet the criteria for 'dependency', with multiple drug abuse being the rule rather than the exception. The age at which adolescents start drug taking is getting lower: an average of 13-15 years. Girls are less likely to use drugs and start later than boys. (...) Earlier illicit drug abuse is often associated with heavier subsequent drug abuse, more persistent abuse, and the abuse of 'harder' drugs.” (p. 1245)

The reader should pay special attention to the mentioned proneness for continued and/or aggravated drug abuse later in life – the fact most probably played a significant role (among other factors) in James falling victim to the opioid epidemic several years later.
Another, probably less surprising, point raised by the interviewee is him struggling with cancer; he does not state it directly, however, taking into account the sole nature of the issue – addiction to prescribed opioids – as well as the condition of medical facilities and care in certain areas, it can be safely assumed that the painkillers James had been prescribed to alleviate the pain related to his illness, were responsible for him developing addiction.
Finally, what the viewer might find unusual, is the method of consuming the drug. In most cases, commonly used prescription painkillers are to be taken orally; obviously, there are certain cases and doses of the medicines that are to be injected, but the injection is usually done by a nurse or another medical professional legally allowed to perform injections (which, in case of opioid painkillers, are muscle injections; James injecting palm suggests that he aims to insert the substance directly into the vein).
The film does also depict one of further interviewees preparing the injection – his method is identical to that of assembling the form of illegal drugs, most notably diacetylmorphine (heroin), that is ready to consume. One can conclude that the director's decision to film the process was supposed to draw similarities between prescription opioids and illicit substances of said type.
But what does James' story include, that would indicate at least a part of the responsibility of developing addiction lies with the person affected? The question seems to be answered by Rena.
The woman shares her experience with lack of self-confidence and being self-conscious of her physical appearance as a teenager. She admits that said struggles contributed to her decision to try self-harming as a method of relieving the mental anguish; as the results of physical pain resulting from the self-inflicted injuries, she was prescribed opioid painkillers. Soon after she began the treatment, she claims to have realised that whereas the medicine did manage to alleviate the bodily discomfort, the side effects – the reason why prescription opioids are used recreationally – provided her with psychological ease much stronger than the one she was able to achieve through self-harming.
Rena also asserts that the prescription abuse – more specifically, the financial struggle that it caused – started the chain of events that lead to her meeting James, her current husband, whom, she claims, helped her finally overcome the self-confidence issues instead of simply temporarily suppressing them with medicine abuse. She did not, however, stop the misuse of OxyContin, and they both have no intention of doing so in the near future. Rena even calls the substance their “love drug”, as she believes that not only did it guide her to encountering James, but also is one of the reasons they still deeply love each other (James agrees with the statement).
Rena's story does in fact provide an example of misusing prescription medicines, and, as a consequence, becoming addicted to them as a result of choosing the misuse as a means of overcoming a problem that concerns a specific individual and/or that could be resolved by other ways of treatment, designed specifically to settling it. Certainly, one could argue that “drive-by appointments” are most probably an issue present in mental health facilities as well, so that even if Rena willed to turn to a professional that would help her accept and admire her physical appearance, the treatment she would have received would not be sufficient, or would even lead to the worsening of the problem. While the point of “drive-by appointments” affecting the quality of the services provided by therapists are satisfactory, the viewer is not introduced to the basis of the woman's decision to start her own “treatment” - while it might have been fuelled by the unavailability of professional help, it might have as well be built upon her own choice not to try any suggested approach.
Furthermore, what also supports the theory of personal responsibility, is the notice of OxyContin being one of the foundations of the couple's successful relationship – a scenario that is rather absurd.
The differentiation between opioid addiction caused by both external and internal (personal) factors was necessary to characterise the issue in greater detail, depicting its vast extent and obstacles in overcoming it caused by the need to find various solutions, suitable for diversified cases.
Both aspects lead to a similar outcome – addiction – that might be discerned by the level of severity associated with surmounting the dependence; the problem itself, however, can result in a condition closely related to, especially psychological, dependence, that should not be omitted when trying to fully understand the dilemma.
According to MedicineNet, substance withdrawal can be defined as:

“Abnormal physical or psychological features that follow the abrupt discontinuation of a drug that has the capability of producing physical dependence.”

Withdrawal occurs in all kinds of abused substances, and thus might vary in severity, length, and symptoms. In case of opioids (both prescription painkillers, and illegal kinds), sudden cease to consume the required item is likely to cause (following Treatment 4 Addiction, An American Addiction Centers Resource)

excessive sweating, independent of the external conditions, occurring usually during the night,
other physical manifestations of withdrawal, namely muscle pain, flu-like symptoms, nausea, diarrhoea, and cramping in lower abdomen,
psychological discomfort – increased anxiety, agitation, insomnia, as well as inability to concentrate.

The aforementioned conditions are of highest intensity during the first five days after stopping the consumption of the substance; next, the individual's body and brain start adapting to function properly without the required intake of the drug.
Nonetheless, there are medicines supposed to nullify the symptoms, and help the addict fight the urge to alleviate physical and mental discomfort by relapsing on opioids. Interestingly, the medicine used in the treatment, Subtex (and several other of its brands), consists mainly of another opioid, buprenorphine; that specific extract of papaver somniferum, while matching the definition for an opioid, does not produce the effects desired to be acquired from recreational use. Such quality allows the body to register the needed dose of opioid, with the individual being unable to achieve any previously seeked reaction, thus allowing the withdrawal period to pass almost unnoticeably (the effectiveness of the treatment varies due to the dose of the opioid the patient was used to receiving).
Naturally, as with any other treatment, no success is guaranteed, since each individual's physical and mental properties might affect the quality of the process. Whereas in most cases the disturbance of the therapy of the discussed condition will lead to temporary noticeable uneasiness and pain, there is a risk of a patient (either subjected to treatment or not) not only being immune to the provided remedy, but also establishing a syndrome including symptoms of severity much greater than those present in classic opioid withdrawal.
In rare cases, the sudden cease of opioid intake might lead to withdrawal-induced psychosis, a state which, in general, can be defined as:

“a loss of contact with reality, usually including false beliefs about what is taking place or who one is and seeing, and hearing things that are not there.”

Psychosis induced by opioids, according to Treatment 4 Addiction, usually manifests with severity greater than the same state induced by other drugs with sedative properties:

“Opiate withdrawal induced psychosis is very different (...). It derives from a place of mental instability and severe anxiety. A sense of hopelessness is very common when in a withdrawal induced psychosis. Judgment and logical thinking are not present during a state of psychosis and can lead to impulsive actions. Depending on the circumstances and possible pre-disposed mental illnesses, a state of psychosis, especially in withdraw, can be extremely dangerous. (...) It is this desperation and hopelessness that will cause an addict to make decisions that may go against their morals or values. (...) This can be very dangerous. Someone in a state of psychosis is extremely unpredictable. Addicts in opiate withdrawal induced psychosis will go to any length to get what they desire.”

Such description – especially regarding making impulsive and hazardous decisions – matches the confession of one of the interviewees, Kurt.
The man describes himself as being in his mid-thirties, and addicted to opioid painkillers (he even shows the drug packages, detailing the doses of the medicine each of them contains, and how much they cost), as well as to unspecified antidepressants.
Before beginning to tell his story, he – similarly to James – injects himself in the back of his palm with a dose of medicines (a painkiller mixed with antidepressants). The viewer might notice that, despite the period of time that has passed since the injection, Kurt does not show any signs of drowsiness, or other symptoms of being under the influence of the substances he has taken. This might suggest that the purpose of the dose in question was to simply avoid the discomfort of withdrawal, not to satisfy the need for the desired effect.
Kurt describes his teenage years in Oceana; the man has never moved out of the town. He used to live with his parents and younger brother, Eric. Both his mother and father were addicted to illegal opioids, which they later replaced with prescription painkillers. His father was also an alcoholic.
In spite of his parents' addiction, the family life was fairly undisturbed by the condition. However, one night, probably as a consequence of a lack of professional help, Kurt's father suffered psychosis caused by untreated withdrawal. The interviewee was not at home that particular night, and, as he now confesses, because of what he discovered after having been back, he believes it was only because of God's providence.
Kurt's father body was scattered on the kitchen floor, next to an empty bottle of an opioid painkiller, and a pistol; his head had a noticeable gunshot wound. The body of the mother was in her bed, dressed in pyjamas – Kurt claims that she was murdered in her sleep. Finally, he found Eric, also dead, lying next to his bed; the body expressed the signs of struggle or defence.
The police concluded that the father, paranoid and desperate to find the drug he needed, found out earlier that his younger son, who had started to grow concern over the parents' dependence, hid the painkillers under his bed. After refusing to give the medicines back to the father, Eric was shot by his father. Next, the man went to the bedroom he shared with his wife, realised she was not woken up by the gunshot, and also murdered her. Eventually, he consumed the medicine he forcefully took from his son, and committed suicide shortly after.
The tragic story of Kurt's family, in its atrociousness, might appear to be an exception, or a part of the very low percentage of extreme cases of prescription abuse. While, according to Bureau of Justice Statistics (BJS), the crimes related to substance abuse (both legal and illegal) in the USA make up only about eighteen percent of all offences, like any other issue, it should not be neglected.
A adduction of a case from outside Oceana might help one realise the severity and omnipresence of this seemingly minor phenomenon.
The city of Mishawaka, Indiana (interestingly, it was not put on the list of the states that are most affected by the opioid epidemic; a proof of the ubiquity of the problem), is one of the places that experienced the issue. An article by Megan Thielking (2017) for Stat News, A Doctor’s Murder Over An Opioid Prescription Leaves An Indiana City With No Easy Answers, quotes the harrowing story of Dr Todd Graham.

“Dr. Todd Graham wasn’t yet halfway through his workday at South Bend Orthopaedics when a new patient came into his office here complaining of chronic pain. Heeding the many warnings of health officials, he told her opioids weren’t the appropriate treatment. But she was accompanied by her husband, who insisted on a prescription. Graham held his ground. The husband grew irate. The argument escalated to the point that Graham pulled out his phone and started recording audio until the couple left. Two hours later, the husband would return, armed. (...) the incident wasn’t out of the ordinary - physicians here and across the country have grown increasingly accustomed to disputes over opioids. (...) Two hours after their verbal scuffle in the orthopaedics office, Michael Jarvis - who had wanted that prescription so badly - had come after him again, this time in the parking lot. Again, Jarvis shouted. He ordered two people at a nearby picnic table to leave. Then he pulled out a semiautomatic weapon and shot the doctor who wouldn’t give his wife pain pills.”

The case quoted above demonstrates even more hazardous side of severe opioid addiction. While the author does not state whether the man who threatened doctor Graham was in the midst of withdrawal, and, consequentially, psychosis, the reader should acknowledge that the prescription Jarvis was demanding was not intended for him, but for his wife. This fact generates several questions – was the culprit lying, as he was convinced the doctor would have been more likely to prescribe the desired medicine for his wife? If so, what was his reason for believing so? Was his mere presence during the appointment supposed to intimidate the doctor and pressure him into providing the prescription? Or was Jarvis addicted to illicit opiates that were not available for him at the moment, and tried to take advantage of the fact that his wife's condition required medical attention? Had he hurt or abused her particularly for this reason?
In the article, the reader will not find the answer for any of the cited questions, which, in fact, makes the specific case – and the whole issue of painkiller addiction and withdrawal – even more horrifying. Each scenario could possibly be true, and, taking into consideration the scale of the epidemic, it can be assumed that that all of the aforementioned probabilities have took place in other cases that did not receive any or enough media attention.
What is more, Doctor Graham's example encourages one to recognise that not only those in close vicinity of the sufferer of psychosis are in immediate danger. The doctor was not in any way related to the murderer, and met his tragic fate only because of trying to properly execute the medical practice by not providing the patient with treatment that would be improper or even harmful for her. Yet again, the scenario establishes another possible one – what if Jarvis learnt about a person, not necessarily associated with medicine, that was currently in possession of an opioid painkiller, and decided to threaten them instead? Such possibility appears even more random, but definitely not absurd, and thus, more alarming.
To support the concept of the jeopardy a third party can be put in because of opioid prescription addiction, Thileking refers to the figures associated with physical and verbal attacks aimed at individuals in their workplace, with the focus on patient-on-doctor violence:

“Health care workers face a disproportionate share of violence in the workplace: An average of 146 attacks for every 10,000 workers, compared to seven assaults per 10,000 workers across the entire U.S. labour force.”

She also mentions the dilemma physicians are often met with when trying to execute the proper treatment:

“First-time patients [such as Jarvis' wife] who are seeking painkillers present a tricky problem for doctors who say they often need considerable time to diagnose what’s wrong with the patient and figure out how best to help. If a patient demands the quick fix of an opioid prescription instead, the situation can swiftly escalate. But doctors say they’re not sure what to do when that happens. They often don’t want to call the police on a patient. Yet they don’t want to give in and write an unnecessary prescription, either.”

Presumably, such puzzling situation doctors are likely to find themselves in, might be the factor that discourages those interested from pursuing a career in medicine; ergo, causing the lack of physicians (“drive-by appointments”) not only in the areas that are affected by the opioid epidemic the most, but also creating the problem in seemingly unaffected areas of The United States.
In order to conclude the analysis of the film in a coherent and logical way, it is best to yet again touch on what commenced it – a statement from the director. This time, Sean Dunne, in an interview with Nick Dawson (2013), rightfully pays respect to those that participated in the production, and, at the same time, restates what has already been aforementioned in the chapter, regarding the cases of the people that might have not been the victims of the phenomenon themselves – how the opioid epidemic affected him both personally and by proxy:

“Certain people were aware of us before we got there and wanted to have their voices heard. Others took a bit more time to warm up to us. But once we got going and got a few interviews under our belt the tide started to shift in our favour, word spread that what we were doing was legit and people began to embrace us. Once our cameras were rolling I couldn’t believe how candid everyone was. We treated them with respect and they did the same in return. (…) The Oxycontin epidemic was somewhat on my radar from personal experiences, but I wasn’t really aware of the full extent of the situation in West Virginia until we went there and saw it firsthand. (...) Obviously when you’re infiltrating and documenting a subject as sensitive as this you are going to be met with some resistance. We had some threats of violence that were very real and extremely nerve wrecking; we even had two death threats. In a town as small as Oceana there is really nowhere to hide, especially with a film crew, so we had to face that stuff head on.”

Later in the interview, Dunne remembers how difficult the process of editing the film was for him and the rest of the filming crew due to the affecting and tragic subject matter, but, in addition to that, he mentions that he is happy for introducing the issue to a large audience.
As the main representative of the problem, included in the present chapter, Oxyana helps the reader in a way infiltrate, as the director himself has mentioned, the psyche and sensitivity of those that were personally involved in prescription opioid abuse, whether by choice, or by the affection of unfortunate circumstances. It rehashes the data presented at the beginning of the chapter – the effects opioids have on the user, their similarity to illegal drugs of the same kind, as well as the problems related solely to the situation a given area struggles with due to the lack of sufficient professional help – and also introduces one to entirely new elements the epidemic, namely the cost of the addiction (financial, as well as health-wise) in an individual, and the black marked of reselling the medicines in question, and means of making money.
In general, the aim of the chapter was to detail the widespread and highly lethal, albeit usually underdiscussed, issue of prescription opioid abuse, by focusing on the most affected demographics and the interesting factors contributing to the people in question falling victim to the epidemic. The presented data has been supported by introducing official statistics that – although most probably not as powerful and emotion-inducing as the direct testimonies provided by Oxyana – prove the unambiguous, yet seemingly contradictory, connection between trying to treat the pain without the adequate supervision and care of a professional, but also with the abundance of physicians to choose from – with developing opioid addiction, the consequences of which are not only detrimental to physical health, but also to the victim's mental condition.